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From I-75...

In Gainesville, take the Williston Rd (Hwy 121) exit, heading West.  Follow until the road ends at Hwy. 41.  Turn Left onto Hwy. 41.  Follow to stop light, turn right onto US Hwy 27A.  Take US Hwy. 27A through Williston.  Holy Family Catholic Church will be on the right side (North side) of US Hwy. 27A, approximately 2 miles out of Williston.

From Hwy 19...

In Chiefland, US Hwy. 19, turn left onto US Hwy. 27A, heading East towards Bronson.  Follow US Hwy. 27A through Bronson.  Holy Family Catholic Church will be on the left side (North Side), approximately 10 miles past Bronson.  (approximately 2 miles before Williston).

From US 441...

In Marion County, turn onto Hwy. 326, heading West.  Take Hwy 326 to US Hwy. 27A, turn right.  Stay on US Hwy. 27A through Williston.  Holy Family Catholic Church will be on the right side (North side) of US Hwy. 27A, approximately 2 miles out of Williston.